Transposon Therapeutics, Inc. Science Pipeline Team News / Literature Connect

Literature

  1. DeCecco M, Ito T, Petrashen AP, et al. L1 drives IFN in senescent cells and promotes age-associated inflammation. Nature. 2019;566(7742):73-78. doi:10.1038/s41586-018-0784-9 (https://pubmed.ncbi.nlm.nih.gov/30728521/)
  2. Frost B, Hemberg M, Lewis J, Feany MB. Tau promotes neurodegeneration through global chromatin relaxation. Nat Neurosci. 2014;17(3):357-366. doi:10.1038/nn.3639 (https://pubmed.ncbi.nlm.nih.gov/24464041/)
  3. Gorbunova V, Seluanov A, Mita P, et al. The role of retrotransposable elements in ageing and age-associated diseases. Nature. 2021;596(7870):43-53. doi:10.1038/s41586-021-03542-y (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600649/)
  4. Guo C, Jeong H-H, Hsieh Y-C, et al. Tau Activates Transposable Elements in Alzheimer’s Disease. Cell Rep. 2018;23(10):2874-2880. (a href="https://pubmed.ncbi.nlm.nih.gov/29874575/" target="_blank" class="white">https://pubmed.ncbi.nlm.nih.gov/29874575/)
  5. Hwang K-D, Bak MS, Kim SJ, Rhee S, Lee Y-S. Restoring synaptic plasticity and memory in mouse models of Alzheimer’s disease by PKR inhibition. Mol Brain. 2017;10(1):57. doi:10.1186/s13041-017-0338-3 (https://pubmed.ncbi.nlm.nih.gov/29233183/)
  6. Liu EY, Russ J, Cali CP, Phan JM, Amlie-Wolf A, Lee EB. Loss of Nuclear TDP-43 Is Associated with Decondensation of LINE Retrotransposons. Cell Rep. 2019;27(5):1409-1421.e6. doi:10.1016/j.celrep.2019.04.003 (https://pubmed.ncbi.nlm.nih.gov/31042469/)
  7. Lopez-Grancha M, Bernardelli P, Moindrot N, et al. A novel selective PKR inhibitor restores cognitive deficits and neurodegeneration in Alzheimer’s disease experimental model. Pharmacol Exp Ther. 2021;378(3):262-275. doi:10.1124/jpet.121.000590 (https://pubmed.ncbi.nlm.nih.gov/34531308/)
Page 1 Page 2
Transposon Therapeutics, Inc. - Logo