Transposon Therapeutics, Inc. Science Pipeline Team News / Literature Connect

Literature

  1. Frost B, Hemberg M, Lewis J, Feany MB. Tau promotes neurodegeneration through global chromatin relaxation. Nat Neurosci. 2014;17(3):357-366. doi:10.1038/nn.3639 (https://pubmed.ncbi.nlm.nih.gov/24464041/)
  2. Guo C, Jeong H-H, Hsieh Y-C, et al. Tau Activates Transposable Elements in Alzheimer’s Disease. Cell Rep. 2018;23(10):2874-2880. (a href="https://pubmed.ncbi.nlm.nih.gov/29874575/" target="_blank" class="white">https://pubmed.ncbi.nlm.nih.gov/29874575/)
  3. Liu EY, Russ J, Cali CP, Phan JM, Amlie-Wolf A, Lee EB. Loss of Nuclear TDP-43 Is Associated with Decondensation of LINE Retrotransposons. Cell Rep. 2019;27(5):1409-1421.e6. doi:10.1016/j.celrep.2019.04.003 (https://pubmed.ncbi.nlm.nih.gov/31042469/)
  4. Thomas CA, Tejwani L, Trujillo CA, et al. Modeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation. Cell Stem Cell. 2017;21(3):319-331.e8. doi:10.1016/j.stem.2017.07.009 (https://pubmed.ncbi.nlm.nih.gov/28803918/)
  5. Rice GI, Meyzer C, Bouazza N, et al. Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome. N Engl J Med. 2018;379(23):2275-2277. doi:10.1056/nejmc1810983 (https://pubmed.ncbi.nlm.nih.gov/30566312/)
  6. Sun W, Samimi H, Gamez M, Zare H, Frost B. Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies. Nat Neurosci. 2018;21(8):1038-1048. doi:10.1038/s41593-018-0194-1 (https://pubmed.ncbi.nlm.nih.gov/30038280/)
  7. Sedivy JM, Kreiling JA, Neretti N, et al. Death by transposition - the enemy within? BioEssays : news and reviews in molecular, cellular and developmental biology. 2013;35(12):1035-1043. doi:10.1002/bies.201300097 (https://pubmed.ncbi.nlm.nih.gov/24129940/)
Page 1 Page 2
Transposon Therapeutics, Inc. - Logo