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PKR
Protein Kinase RDownstream druggable targets in the LINE-1 pathway, such as Protein Kinase R (PKR), may be additive or synergistic with LINE-1 reverse transcriptase inhibitor treatment.
Protein kinase R (PKR) is elevated in the cerebrospinal fluid of Alzheimer’s Disease patients, and the degree of elevation correlates with severity of cognitive impairment. Knock-out of the PKR gene in mice leads to improved cognition and memory formation. Small molecule PKR inhibitors have been shown to improve memory and cognition in mouse models.
Our PKR inhibitor discovery program evaluates innovative small molecules for the treatment of compromised cognition and memory associated with central nervous system diseases.
Our PKR inhibitor discovery program evaluates innovative small molecules for the treatment of compromised cognition and memory associated with central nervous system diseases.