Transposon is developing TPN-101 (aka Censavudine) to treat neurodegenerative diseases of high unmet medical need. TPN-101 has excellent systemic and brain bioavailability following once-daily oral dosing and is well tolerated based on exposures of over 250 subjects for approximately 48 weeks.

Promising exploratory Phase 2 results support Phase 3 evaluation of TPN-101 in PSP and ALS, as well as initiation of studies in Alzheimer’s Disease.

PSP ALS/FTD AD

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